What we do
University of Manchester

The Sinthetic Biology Research Centre at the University of Manchester aims to develop faster and more reliable “greener” routes to speciality chemicals production, having developed an automated Design-Build-Test-Learn pipeline for discovery and optimisation of biosynthetic pathways




What we do

The University of Manchester (UNIMAN) is the largest single-site university in the UK, with research strength across all scientific disciplines.

The Manchester Institute of Biotechnology (MIB): As the first university-based, purpose-built interdisciplinary research institute of its kind in the UK and one of the leading biotechnology research institutes in the world, MIB is an industry-interfaced institute with a strong international profile and global reach that is driving bio-based chemicals synthesis, and is a widely acknowledged beacon of interdisciplinary bioscience with internationally recognised unrivalled facilities.

Based within the MIB, the Research Council UK funded (>£10M) Synthetic Biology (SynBio) Research Centre, SYNBIOCHEM, which is harnessing SynBio to develop faster, more predictable, novel routes for fine and speciality chemicals production to deliver new chemical diversity towards scale-up and industrial manufacturing, likely to impact across many sectors (e.g. healthcare, energy, green chemistry, pharmaceuticals and novel materials. The Centre unites 29 UNIMAN academic groups from across the disciplines and provides a suite of fully integrated “Design/Build/Test” technology and Data management platforms whilst addressing emerging societal, ethical, and regulatory challenges (Responsible Research and Innovation, RRI) associated with this rapidly advancing technology.

SYNBIOCHEM is differentiated from other academic centres by strengthening its SynBio capabilities with deep understanding of catalysis/chemical science, mechanistic and systems biology, data management, computation and informatics – all globally recognised strengths in MIB. This enables SYNBIOCHEM to rapidly expand, implement and integrate its frontier knowledge of enzyme design, directed evolution and retrosynthetic methodology into its synthetic biology workflows, which pulls away from automated ‘cut and paste’ biology that is often a central feature of foundries.

The evidence base for the competitive standing of SYNBIOCHEM is outstanding: 263 peer reviewed publications (many in Nature, Science and similar journals); a spin-out company, multiple patents, disclosures and commercial activities; a pipeline of innovative technologies/software developments; a widely adopted data management infrastructure; multiple industry/international co-development partnerships; a large postgraduate training school (160 registered since 2014); additional competitive funding (£33M) to sustain future activities.

Find out more about the University of Manchester here.



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Partners

SilicoLife
SilicoLife

Braga, Portugal

SilicoLife
SilicoLife designs optimised microorganisms and novel pathways for industrial biotech applications.
EPFL
EPFL

Vaud, Switzerland

EPFL
EPFL was founded in 1969 and has established itself among the world’s best research and teaching institutions.
DTU
DTU

Copenhagen, Denmark

DTU
Technical University of Denmark (DTU) is recognised internationally in the areas of technology and the natural sciences.
EMBL
EMBL

Heidelberg, Germany

EMBL
EMBL is Europe’s flagship laboratory for life sciences.
DSM
DSM

Delft, Netherlands

DSM
DSM is a global science-based company active in health, nutrition and materials.
University of Manchester
University of Manchester

Manchester, United Kingdom

University of Manchester
The University of Manchester is the largest single-site university in the UK, with research strength across all science disciplines.
University of Minho
Uminho

Braga, Portugal

University of Minho
The University of Minho has expertise in the development of algorithms and computational tools for metabolic engineering.
NOVA University of Lisbon
Nova

Lisbon, Portugal

NOVA University of Lisbon
NOVA University Lisbon is the youngest of Lisbon's state Univiersities.
c-LEcta
c-LEcta

Leipzig, Germany

c-LEcta
c-LEcta is specialised on the discovery, optimisation and production of enzymes and the strain engineering for protein and small molecule production
GalChimia
GalChimia

La Coruña, Spain

GalChimia
GalChimia is a service provider focused in the filed of Synthetic Organic Chemistry.
NNFCC
NNFCC

York, United Kingdom

NNFCC
NNFCC has over 14 years of experience in supporting the development of bio-based chemicals and products.
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