What we do
SilicoLife

SilicoLife designs optimized microorganisms and novel pathways for industrial biotechnology applications based on metabolic engineering and synthetic biology approaches that shorten development times and costs associated with new highly effective processes for the production of specific target compounds, such as chemicals, food ingredients or biopolymers.




What We Do

SilicoLife builds computational models of microbial cells and develops proprietary state-of-the-art algorithms to find the most efficient pathways between raw-materials and end-products, enabling clients to streamline the strain design process and explore non-intuitive pathway modifications, dramatically cutting down costs in their development programs and reducing laboratory experimentation. SilicoLife provides the complete package, from genomic annotation to the validation of optimized microbial strains, and also the evaluation of incorporated heterologous pathways into host cells. Optimized strains allow for increased productivity and yields associated with bio-processes through maximizing fluxes in metabolic pathways, linking raw-material uptake with product production.

Many leading chemical, materials, and synthetic biology companies have chosen SilicoLife as a development partner, to maintain their competitive edge within the market. SilicoLife is also a partner in several European projects, such as H2020 DD-DeCaF – bioinformatics services for data-driven design of cell factories and communities; FP7 BRIGIT – development of the next generation of bio-based polymers; several projects in the ERA-NET on Industrial Biotechnology and Marine Biotechnology; and also leads on national Portuguese initiatives surrounding industrial biotechnology topics.

Within the ShikiFactory100 project, SilicoLife's key roles are as principal coordinators of the project and they are leaders of Work Package 1: Management, which oversees the smooth running of project in its entirety. SilicoLife are also  heavily involved in research activities, as leaders of Work Package 2: Retrosynthesis & Enumeration, and as contributors to Work Package 5: In silico Metabolic Engineering; Work Package 6: Rapid Prototyping & Screening; and Work Package 7: Cell Factory Construction. 

The Principal Investigator for SilicoLife in the ShikiFactory100 project is Simão Soares. He is also a member of the project's management team as Project Coordinator, alongside colleague Paulo Maia who is the project's Assistant Coordinator. 

Find out more about SilicoLife here.




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Partners

SilicoLife
SilicoLife

Braga, Portugal

SilicoLife
SilicoLife designs optimised microorganisms and novel pathways for industrial biotech applications.
EPFL
EPFL

Vaud, Switzerland

EPFL
EPFL was founded in 1969 and has established itself amongst the world’s best research and teaching institutions.
DTU
DTU

Copenhagen, Denmark

DTU
Technical University of Denmark (DTU) is recognised internationally in the areas of technology and natural sciences.
EMBL
EMBL

Heidelberg, Germany

EMBL
EMBL is Europe’s flagship laboratory for life sciences.
DSM
DSM

Delft, Netherlands

DSM
DSM is a global science-based company active in health, nutrition and materials.
University of Manchester
University of Manchester

Manchester, United Kingdom

University of Manchester
The University of Manchester is the largest single-site university in the UK, with research strengths across all scientific disciplines.
University of Minho
UMinho

Braga, Portugal

University of Minho
The University of Minho has expertise in the development of algorithms and computational tools for metabolic engineering.
Universidade NOVA de Lisboa
NOVA

Lisbon, Portugal

Universidade NOVA de Lisboa
Universidade NOVA de Lisboa is the youngest of Lisbon's state universities.
c-LEcta
c-LEcta

Leipzig, Germany

c-LEcta
c-LEcta specializes on the discovery, optimization and production of enzymes and engineered strains for the production of proteins and small molecules.
GalChimia
GalChimia

La Coruña, Spain

GalChimia
GalChimia is a service provider focused in the field of synthetic organic chemistry.
NNFCC
NNFCC

York, United Kingdom

NNFCC
NNFCC has over 17 years of experience in supporting the development of bio-based chemicals and products.
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